Predictive assessment of micro RNA expression level and number of nucleolar organizer regions with follicular thyroid tumor of undetermined malignant potential

Introduction This article presents the current views on follicular thyroid tumor of undetermined malignant potential (FTUMP) taking into account principles WHO classification. Molecular genetic study with identification mutation some genes as well determination expression level microRNAs are given methods for detection predictors oncodiagnostics. It was shown that state nucleus organizer regions is a marker cell proliferation rate. The aim investigation to estimate prognostic significance and amount organizers in tissue at FTUMP objectify approaches development adequate surgical tactics. Materials Profile, microRNA by real time PCR were studied 98 cases which made up 4.75% all tumors operated during four years. Results In 29 (29.6%) spectrum typical neoplasms registered FTUMP. remaining 69 (70.4%) out observations corresponded adenoma. Statistically significant differences average number AgNORs correlation between area granules found within formed subgroups. Discussion Increase mean ratio silver nitrate 2nd subgroup comparison 1st one, appearance type II cells testifies proliferating new growth can be considered criteria malignization. These results correlate findings molecular-genetic . Conclusion data literature obtained studying profile microRNAs, morphometric characteristics counting thyrocyte may serve additional evaluation proliferative activity epithelium neoplasms, particular clarify malignancy potential. Preoperatively diagnosed conditionally will allow justify necessity intervention, if complex benign revealed, stick waiting tactics refuse intervention.